L-Glutathione yog dab tsi?

L-Glutathione hmoov, feem ntau hu ua glutathione, yog ib qho tseem ceeb antioxidant pom nyob rau hauv peb lub cev. Nws ua lub luag haujlwm tseem ceeb hauv ntau yam txheej txheem physiological, suav nrog kev tshem tawm cov tshuaj lom, tiv thaiv kab mob, thiab kho cellular.

Understanding Glutathione

Glutathione hmoov yog ib qho tripeptide uas muaj peb cov amino acids: cysteine, glycine, thiab glutamic corrosive. Nws yog synthesized nyob rau hauv daim siab thiab yuav pom nyob rau hauv yuav luag txhua cell ntawm lub cev. Ib qho ntawm nws qhov tseem ceeb muaj peev xwm yog ua kom tsis txhob muaj cov dawb radicals thiab txais cov pa oxygen (ROS), uas yog cov khoom tsim kev puas tsuaj ntawm lub plab zom mov thiab cov tshuaj lom neeg. Yeej, glutathione ua raws li lub zog antioxidant, ruaj cov hlwb los ntawm oxidative thawb thiab puas.

Glutathione yog ib qho tseem ceeb antioxidant thiab tripeptide zaub nyob rau hauv yuav luag txhua lub cell hauv lub cev. Tsim los ntawm peb cov amino acids - glutamine, cysteine, thiab glycine - nws plays lub luag haujlwm tseem ceeb hauv ntau hom physiological, suav nrog:

Antioxidant tiv thaiv: Glutathione yog ib qho tseem ceeb ntawm lub cev tiv thaiv kab mob qog noj ntshav, ua qhov sib txawv los ua kom tsis muaj mob dawb radicals thiab teb cov kab mob oxygen (ROS) uas tuaj yeem ua mob hlwb thiab DNA. Nws ruaj ntseg tiv thaiv oxidative thawb, uas txuas nrog rau kev loj hlob, khaus khaus, thiab cov kab mob inveterate xws li mob qog noj ntshav, mob plawv, thiab cov kab mob neurodegenerative.

DNA Kho thiab Amalgamation: Glutathione pab txhawb DNA kho cov cuab yeej hauv cov hlwb, tiv thaiv DNA raug mob los ntawm oxidative thawb, tshuaj lom, thiab cov khoom ntuj tsim. Nws ua rau muaj qhov sib txawv ua kom muaj kev ruaj khov thiab mob siab rau, txo txoj hauv kev ntawm kev hloov pauv, kev puas tsuaj ntawm tes, thiab carcinogenesis.

Cellular Redox Kho: Glutathione muaj nyob rau hauv kev ua kom cov cellular redox kho, uas alludes rau kev sib haum xeeb ntawm oxidants (xws li dawb radicals) thiab tshuaj tiv thaiv mob qog noj ntshav hauv hlwb. Nws coj redox-rhiab qhov taw qhia txoj hauv kev thiab cov proteins, cuam tshuam cov cellular sib txawv, suav cov plab zom mov, nthuav dav, apoptosis, thiab kev qhia zoo.

Protein Structure thiab Kev Ua Haujlwm: Glutathione ua ib feem hauv kev coj cov qauv protein, kev ua haujlwm, thiab kev hloov pauv hauv cov hlwb. Nws ua kom muaj qhov sib txawv kom ntseeg tau cov proteins los ntawm oxidative kev puas tsuaj, ua rau cov protein sib tsoo, thiab txhawb kev khiav tawm ntawm cov proteins uas raug mob lossis misfolded. Txoj haujlwm no yog qhov tseem ceeb rau kev khaws cov cellular homeostasis thiab zam kev sib xyaw ua ke ntawm cov protein.

Kev tsim hluav taws xob: Glutathione pab txhawb lub zog metabolism los ntawm kev koom tes hauv kev sib txuas thiab kev siv ntawm adenosine triphosphate (ATP), thawj lub zog txiaj ntawm cov hlwb. Nws txhawb nqa mitochondrial muaj nuj nqi, oxidative phosphorylation, thiab cellular respiration, ua kom muaj zog ntau lawm thiab cellular vitality.

Zuag qhia tag nrho, glutathione yog cov khoom siv ntau yam uas yog qhov tseem ceeb rau kev tswj hwm cellular kev noj qab haus huv, txhawb kev tiv thaiv kab mob, tiv thaiv oxidative kev nyuaj siab thiab co toxins, thiab tswj ntau yam txheej txheem physiological hauv lub cev. Cov qib glutathione txaus yog qhov tseem ceeb rau kev noj qab haus huv thiab kev noj qab haus huv tag nrho, thiab cov tswv yim los txhim kho glutathione ntau lawm los yog ntxiv yuav muaj txiaj ntsig zoo hauv kev txhawb nqa kev noj qab haus huv thiab tiv thaiv kab mob.

Lub luag haujlwm hauv detoxification

Detoxification yog txheej txheem tseem ceeb uas pab lub cev tshem tawm cov co toxins thiab cov pa phem. Glutathione ua lub luag haujlwm tseem ceeb hauv cov txheej txheem no los ntawm kev khi rau cov co toxins thiab ua kom yooj yim tshem tawm ntawm lub cev los ntawm cov zis los yog kua tsib. Nws kuj txhawb kev ua haujlwm ntawm lwm cov detoxification enzymes, xws li glutathione peroxidase thiab glutathione S-transferase. Yog tias tsis muaj qib glutathione txaus, lub cev yuav tawm tsam kom tshem tawm cov co toxins, ua rau muaj kev pheej hmoo ntawm oxidative puas tsuaj thiab ntau yam teeb meem kev noj qab haus huv.

Zaug Kev Pab

Lub cev tiv thaiv kab mob tso siab rau glutathione ua haujlwm zoo. Cov tshuaj antioxidant no pab tswj lub cev tiv thaiv kab mob los ntawm kev hloov kho cov haujlwm ntawm lub cev tiv thaiv kab mob, xws li T hlwb, B hlwb, thiab cov cell killer ntuj. Tsis tas li ntawd, glutathione txhim kho kev tsim khoom thiab kev ua haujlwm ntawm cov tshuaj tiv thaiv kab mob, uas yog qhov tseem ceeb rau kev tawm tsam cov kab mob thiab cov kab mob. Qib qis ntawm glutathione tau cuam tshuam nrog kev cuam tshuam ntawm lub cev tsis muaj zog thiab ua rau muaj kev kis kab mob ntau ntxiv.

Cellular Kho thiab Anti-aging

Glutathione hmoov plays lub luag haujlwm tseem ceeb hauv kev kho cellular thiab rov tsim dua tshiab. Nws pab tswj kev ncaj ncees ntawm cell membranes, proteins, thiab DNA los ntawm kev tiv thaiv lawv los ntawm oxidative puas. Qhov no yog qhov tseem ceeb tshwj xeeb rau kev noj qab haus huv ntawm daim tawv nqaij, vim glutathione pab tiv thaiv oxidative kev nyuaj siab vim kev laus thiab tswj cov tawv nqaij cov hluas. Tsis tas li ntawd, glutathione txhawb kev tsim cov collagen, cov protein tseem ceeb rau daim tawv nqaij elasticity thiab firmness.

Health Cov txiaj ntsig ntawm Glutathione

Cov txiaj ntsig kev noj qab haus huv ntawm glutathione txuas ntxiv tshaj nws cov khoom antioxidant. Kev tshawb fawb qhia tias cov qib glutathione txaus yuav pab txo qis kev pheej hmoo ntawm cov kab mob ntev, xws li kab mob plawv, ntshav qab zib, thiab mob qog noj ntshav. Nws kuj tseem ua lub luag haujlwm hauv kev txo cov teebmeem ntawm cov kab mob neurodegenerative, suav nrog Alzheimer's thiab Parkinson's disease. Tsis tas li ntawd, glutathione tau kawm txog nws cov teebmeem kev kho mob hauv cov mob xws li mob hawb pob, kab mob siab, thiab mob autoimmune.

Qhov chaw ntawm Glutathione

Thaum lub cev tuaj yeem tsim cov glutathione endogenously, qee yam tuaj yeem ua rau nws txo qis, suav nrog kev laus, kev ntxhov siab, kev noj zaub mov tsis zoo, thiab ib puag ncig co toxins. Hmoov zoo, muaj ntau qhov chaw noj zaub mov ntawm glutathione uas tuaj yeem pab tswj qib siab. Cov khoom noj uas muaj sulfur-muaj cov amino acids, xws li cysteine ​​thiab methionine, tshwj xeeb tshaj yog rau glutathione synthesis. Cov no suav nrog qej, dos, zaub cruciferous, qe, thiab lean protein qhov chaw xws li ntses thiab nqaij qaib.

Supplementation

Qee qhov xwm txheej, kev siv tshuaj ntxiv yuav tsim nyog los txhawb cov qib glutathione, tshwj xeeb tshaj yog rau cov tib neeg uas muaj qee yam kev mob nkeeg lossis cov uas muaj kev nyuaj siab oxidative. Muaj ntau hom tshuaj glutathione, suav nrog cov tshuaj ntsiav hauv qhov ncauj, ntsiav tshuaj sublingual, thiab txhaj tshuaj txhaj. Txawm li cas los xij, nws yog ib qho tseem ceeb uas yuav tau xaiv cov khoom zoo los ntawm cov npe nrov kom muaj kev nyab xeeb thiab ua tau zoo. Tsis tas li ntawd, kev sab laj nrog tus kws kho mob ua ntej pib cov txheej txheem ntxiv yog pom zoo.

xaus

Thaum xaus, L-Glutathione hmoov yog ib qho tseem ceeb antioxidant nrog ntau cov txiaj ntsig kev noj qab haus huv. Nws lub luag haujlwm hauv detoxification, tiv thaiv kev tiv thaiv, kho cellular, thiab tiv thaiv kev laus ua rau nws yog ib qho tseem ceeb molecule rau tag nrho cov kev noj qab haus huv thiab kev noj qab haus huv. Thaum lub cev tuaj yeem tsim cov glutathione ib txwm muaj, kev tswj hwm qib zoo yuav xav tau kev sib xyaw ua ke ntawm kev noj qab haus huv kev noj qab haus huv, kev cuam tshuam kev noj haus, thiab kev pabcuam ntxiv thaum tsim nyog. Los ntawm kev nkag siab txog qhov tseem ceeb ntawm glutathione thiab ua cov kauj ruam los txhawb nws cov kev tsim khoom, cov tib neeg tuaj yeem txhim kho lawv txoj kev ua haujlwm zoo rau oxidative kev nyuaj siab thiab txhawb nqa lub neej ntev.

References:

1. National Center for Biotechnology Information. (nd). Glutathione: Txheej txheem cej luam. Rov qab los ntawm https://pubchem.ncbi.nlm.nih.gov/compound/Glutathione

2. Rahman, I., & Adcock, IM (2006). Glutathione homeostasis nyob rau hauv alveolar epithelial cell. Rov qab los ntawm https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738786/

3. Richie Jr, JP, & Nichenametla, S. (2009). Glutathione thiab nws lub luag haujlwm hauv kev laus thiab kev ua neej ntev. Rov qab los ntawm https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250776/

4. Witschi, A., & Reddy, S. (2013). Glutathione thiab nws cov haujlwm hauv kev noj qab haus huv thiab kab mob. Rov qab los ntawm https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684116/

5. Ballatori, N., Krance, SM, Marchan, R., & Hammond, CL (2009). Glutathione dysregulation thiab etiology thiab kev loj hlob ntawm tib neeg cov kab mob. Rov qab los ntawm https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769390/