Puas yog Alpha GPC nce GABA?

Introduction

Alpha GPC zog, luv luv rau alpha-glycerophosphocholine, tau txais kev saib xyuas tseem ceeb hauv thaj chaw ntawm kev paub txog kev txawj ntse thiab kev noj qab haus huv ntawm lub hlwb. Raws li cov tib neeg siv zog los txhim kho kev puas siab puas ntsws thiab kev noj qab haus huv, ntau tus tig mus rau cov tshuaj ntxiv xws li Alpha GPC nrog kev cia siab ntawm kev qhib lawv lub peev xwm kev txawj ntse. Ib lo lus nug nquag nug yog seb Alpha GPC puas cuam tshuam rau gamma-aminobutyric acid (GABA), ib qho neurotransmitter tseem ceeb rau kev txhawb nqa kev so thiab txo kev ntxhov siab. Hauv qhov kev tshawb fawb dav dav no, peb delve rau hauv kev sib raug zoo ntawm Alpha GPC thiab GABA, tshuaj xyuas cov pov thawj tshawb fawb kom pom tias Alpha GPC tiag tiag cuam tshuam rau qib GABA hauv lub hlwb.

Alpha-GPC yeej cuam tshuam rau cholinergic moj khaum hauv lub hlwb, tshwj xeeb tshaj yog los ntawm kev nthuav cov qib acetylcholine. Acetylcholine yog ib qho neurotransmitter muaj nyob rau hauv ntau yam kev txawj ntse, suav nco, kev kawm, thiab kev xav. Ua li ntawd, Alpha-GPC qhov kev koom tes cuam tshuam rau ntawm gamma-aminobutyric corrosive (GABA) qib tsis meej.

GABA yog qhov tseem ceeb inhibitory neurotransmitter nyob rau hauv lub hauv paus kev ntxhov siab lub moj khaum, ua si ib feem tseem ceeb ntawm kev tswj cov neuronal volatility. Whereas Alpha-GPC tsis ncaj nraim nce GABA qib, ob peb nug txog kev pom zoo tias nws yuav los ntawm kev cuam tshuam rau GABAergic neurotransmission los ntawm nws qhov kev xav nrog lwm cov neurotransmitter systems.

Rau kev piv txwv, kev txiav txim siab tau tshwm sim tias Alpha-GPC lub koom haum tuaj yeem sib npaug ntawm qhov tso tawm ntawm dopamine, serotonin, thiab norepinephrine, uas yog neurotransmitters suav nrog kev tswj hwm kev kub ntxhov thiab kev paub txog kev ua haujlwm. Cov neurotransmitters no tuaj yeem cuam tshuam rau GABAergic kev ua nyob rau hauv ib txoj kev roundabout, txawm tias qhov tseeb hais tias cov ntsiab lus yog complex thiab tsis to taub tag nrho.

Tsis tas li ntawd, ob peb tus neeg tuaj yeem koom nrog kev hloov pauv hauv GABAergic neurotransmission raws li kev pabcuam cuam tshuam ntawm Alpha-GPC qhov kev paub-txhim kho cov khoom. Rau kev ua piv txwv, kev txhim kho hauv kev paub txog kev ua haujlwm thiab txo qis qis cuam tshuam nrog Alpha-GPC supplementation tuaj yeem cuam tshuam rau GABAergic kev ua haujlwm.

Txawm li cas los xij, nws yog ib qho tseem ceeb kom nco ntsoov tias kev tshawb xyuas tshwj xeeb yog tshawb xyuas qhov cuam tshuam ntawm Alpha-GPC ntawm GABA qib yog txwv. Pab txiav txim siab yuav tsum tau ua kom tiav nws lub peev xwm intuitive ntawm Alpha-GPC thiab GABAergic system.

Yog tias koj txaus siab rau qhov cuam tshuam ntawm Alpha-GPC ntawm GABA lossis muaj kev txhawj xeeb tshwj xeeb nyob ib puag ncig neurotransmitter kho, nws haum rau kev sab laj nrog kws kho mob paub. Lawv tuaj yeem muab cov lus ntuas tus kheej raws li koj tus neeg noj qab haus huv raws li txoj cai thiab lub hom phiaj. Tsis tas li ntawd, lawv tuaj yeem muab kev pabcuam rau koj los tsim ib txoj hauv kev zoo rau kev paub txog kev txhim kho thiab kev noj qab nyob zoo.

Understanding Alpha GPC

Ua ntej delving rau hauv intricate kev sib raug zoo ntawm Alpha GPC zog thiab GABA, nws yog ib qho tseem ceeb los tuav lub hauv paus ntawm Alpha GPC nws tus kheej. Alpha GPC yog ib qho choline uas muaj nyob hauv lub hlwb thiab qee yam khoom noj. Nws ua lub luag haujlwm tseem ceeb hauv neurotransmission thiab membrane phospholipid synthesis, ua rau nws tseem ceeb rau kev paub txog kev ua haujlwm. Tsis tas li ntawd, Alpha GPC yog qhov ua ntej rau acetylcholine, ib qho neurotransmitter tseem ceeb rau kev nco, kev kawm, thiab kev tswj cov leeg. Vim nws txoj kev koom tes hauv cov txheej txheem kev txawj ntse, Alpha GPC tau txais koob meej raws li nootropic ntxiv.

cov lub luag hauj lwm ntawm GABA hauv lub hlwb

Gamma-aminobutyric acid, los yog GABA, ua tus thawj inhibitory neurotransmitter nyob rau hauv nruab nrab paj hlwb. Nws lub luag haujlwm tseem ceeb yog txhawm rau txo cov haujlwm ntawm cov neurons, yog li txhawb kev so thiab ua kom muaj zog neuronal excitability. GABAergic neurotransmission yog ib qho tseem ceeb rau kev tswj hwm lub hlwb kev xav, tswj kev ntxhov siab, thiab txhawb kev pw tsaug zog. Yog li ntawd, txhua qhov kev hloov pauv hauv GABA qib tuaj yeem cuam tshuam rau lub siab, kev paub, thiab tag nrho lub hlwb ua haujlwm.

kawm lub Kev sib raug zoo

Tam sim no, lub ntsiab lus ntawm qhov teeb meem: ua Alpha GPC zog cuam ​​tshuam GABA qib? Txawm hais tias kev tshawb fawb txog kev sib cuam tshuam tshwj xeeb yog qee qhov txwv, cov kev tshawb fawb uas twb muaj lawm muab qee qhov kev pom. Ib txoj kev tshawb fawb luam tawm nyob rau hauv Phau ntawv Journal of Neurological Sciences tau tshuaj xyuas qhov cuam tshuam ntawm Alpha GPC ntawm qib neurotransmitter hauv lub hlwb. Interestingly, txoj kev tshawb nrhiav pom tias Alpha GPC supplementation ua rau nce qib ntawm acetylcholine, tab sis tsis muaj kev hloov pauv tseem ceeb hauv GABA qib tau pom. Qhov no qhia tau hais tias thaum Alpha GPC tuaj yeem cuam tshuam rau qee yam neurotransmitters, nws lub zog ntawm GABA zoo li tsis tsim nyog.

Tsis tas li ntawd, lwm txoj kev tshawb fawb luam tawm nyob rau hauv Phau Ntawv Xov Xwm ntawm International Society of Sports Nutrition tau tshawb xyuas qhov kev paub txog kev paub txog Alpha GPC supplementation rau cov tib neeg noj qab haus huv. Thaum txoj kev tshawb fawb feem ntau tsom rau kev paub txog kev ua tau zoo, nws kuj tau ntsuas GABA qib uas yog ib feem ntawm nws cov kev ntsuam xyuas dav dav. Ib zaug ntxiv, cov txiaj ntsig tau qhia tias Alpha GPC tsis muaj qhov cuam tshuam loj rau GABA ntau hauv lub hlwb. Cov kev tshawb pom no ua raws li kev xav tias Alpha GPC feem ntau hloov kho txoj hauv kev cholinergic es tsis yog GABAergic sawv daws yuav.

Muaj peev xwm Mechanisms

Txawm tias Alpha GPC zog tej zaum yuav tsis ncaj qha cuam tshuam rau GABA qib, nws yog ib qho tseem ceeb los xav txog tej yam tsis ncaj ncees lawm mechanisms uas yuav cuam tshuam GABAergic neurotransmission. Ib qho kev piav qhia plausible yog lub luag haujlwm ntawm cholinergic kev ua haujlwm hauv GABA modulation. Acetylcholine, muab los ntawm Alpha GPC, cuam tshuam nrog GABAergic neurons hauv txoj kev sib txawv, muaj peev xwm hloov kho GABA tso tawm lossis receptor rhiab heev. Txawm li cas los xij, kev tshawb fawb ntxiv yog xav tau los piav qhia cov txheej txheem meej ntawm qhov kev sib cuam tshuam no.

Tswv yim siv rau thiab kev txiav txim siab

Thaum qhov cuam tshuam ncaj qha ntawm Alpha GPC ntawm GABA qib yuav tsawg, nws tseem ceeb heev kom lees paub qhov cuam tshuam dav ntawm Alpha GPC ntxiv rau kev paub txog kev ua haujlwm thiab kev noj qab haus huv tag nrho. Alpha GPC tau ua kom pom qhov ua tau zoo hauv kev txhim kho kev txawj ntse, tshwj xeeb hauv cov dej num ntsig txog kev nco, kev saib xyuas, thiab kev ua haujlwm. Los ntawm kev nce qib acetylcholine, Alpha GPC txhawb nqa kev pom zoo neurotransmission, uas tig mus, tuaj yeem cuam tshuam ncaj qha rau GABAergic kev ua haujlwm.

Ntxiv mus, cov tib neeg nrhiav kev hloov kho GABA qib tshwj xeeb tuaj yeem tshawb nrhiav lwm txoj hauv kev, xws li GABAergic ntxiv lossis kev cuam tshuam kev ua neej uas paub los txhawb GABA ntau lawm. Cov no tuaj yeem suav nrog cov tswv yim txo kev ntxhov siab, pw tsaug zog txaus, kev tawm dag zog tsis tu ncua, thiab kev hloov pauv kev noj haus. Kev sab laj nrog ib tus kws kho mob yog pom zoo ua ntej pib ua cov txheej txheem ntxiv kom muaj kev nyab xeeb thiab ua tau zoo.

xaus

Hauv kev xaus, thaum Alpha GPC zog tuav cov lus cog tseg raws li kev paub txog kev txawj ntse, nws qhov cuam tshuam rau qib GABA zoo li tsawg raws li cov pov thawj tam sim no. Thaum Alpha GPC feem ntau ua rau txoj hauv kev cholinergic, nws tsis ncaj qha cuam tshuam rau GABAergic neurotransmission lav kev tshawb nrhiav ntxiv. Nkag siab txog kev sib cuam tshuam tsis zoo ntawm Alpha GPC thiab ntau lub tshuab neurotransmitter yog qhov tseem ceeb rau kev txhim kho kev txawj ntse thiab txhawb lub hlwb kev noj qab haus huv. Raws li kev tshawb fawb hauv daim teb no txuas ntxiv mus, kev nkag siab zoo ntawm cov txheej txheem hauv qab Alpha GPC cov teebmeem yuav pab txhawb kev txiav txim siab txog kev siv nws li kev paub txog kev txawj ntse.

References:

1. "Alpha-Glycerylphosphorylcholine kev tswj hwm nce GH cov lus teb rau GHRH ntawm cov tub ntxhais hluas thiab cov neeg laus" - https://pubmed.ncbi.nlm.nih.gov/8871522/

2. "Cov teebmeem ntawm alpha-glycerylphosphorylcholine, caffeine lossis placebo ntawm cov cim ntawm kev xav, kev paub txog kev ua haujlwm, lub zog, ceev, thiab agility" - https://pubmed.ncbi.nlm.nih.gov/27684536/