Kuv puas tuaj yeem noj L glutathione nrog vitamin E?
Kuv puas tuaj yeem noj L-Glutathione nrog Vitamin E?
Raws li ib tus neeg paub txog kev noj qab haus huv, koj tuaj yeem pom koj tus kheej xav paub txog cov txiaj ntsig thiab kev cuam tshuam ntawm ntau yam tshuaj. Ntawm cov plethora ntawm kev xaiv muaj, L-Glutathione zog thiab vitamin E sawv tawm rau lawv cov khoom muaj npe antioxidant thiab txhawb kev noj qab haus huv. Txawm li cas los xij, ua ntej muab cov tshuaj ntxiv, nws yog ib qho tseem ceeb kom nkag siab txog lawv cov txheej txheem ntawm kev ua, kev sib cuam tshuam, thiab kev sib raug zoo tag nrho.
Yog lawm, koj tuaj yeem ua rau feem ntau noj L-glutathione nrog cov vitamin E, thiab qhov tseeb, lawv tuaj yeem txhawb nqa ib leeg los ntawm kev noj qab haus huv loj thiab tiv thaiv antioxidant. Nov yog qhov lawv tuaj yeem ua haujlwm ua ke:
Antioxidant Cooperative zog: Ob leeg L-glutathione thiab vitamin E yog cov tshuaj tiv thaiv kabmob kheesxaws uas muaj kev pabcuam kom cov hlwb los ntawm oxidative raug mob los ntawm cov dawb radicals. Dawb radicals yog cov khoom tsis ruaj khov uas tuaj yeem ua rau muaj kev puas tsuaj ntawm tes thiab ua rau muaj kev noj qab haus huv sib txawv, suav nrog kev loj hlob, ua rau hnyav dua, thiab mob tsis tu ncua. Los ntawm kev noj L-glutathione thiab vitamin E ua ke, koj tuaj yeem hloov kho koj lub cev cov tshuaj tiv thaiv antioxidant thiab rov qab rau kev noj qab haus huv.
Regeneration of Cancer Prevention agents: Ib qho ntawm cov khoom zoo ntawm L-glutathione yog nws txoj hauv kev rov qab los ntawm lwm cov tshuaj tiv thaiv kabmob kheesxaws, suav cov vitamin E. Tom qab vitamin E neutralizes dawb radical, nws tau oxidized. L-glutathione ua rau muaj qhov sib txawv rov qab oxidized vitamin E rov qab mus rau nws cov duab zoo, tso cai rau nws ua nws cov haujlwm antioxidant hauv lub cev. Qhov kev hloov pauv ntawm L-glutathione thiab vitamin E qhia txog lawv txoj kev sib koom tes hauv kev tawm tsam oxidative kev nyuaj siab.
Immune Back: Ob leeg L-glutathione thiab vitamin E ua si qhov tseem ceeb hauv kev txhawb nqa kev nyab xeeb. Los ntawm kev txo qis oxidative thawb thiab khaus khaus, lawv muab kev pabcuam kom muaj suab nrov tiv thaiv thiab tiv thaiv kab mob thiab kab mob.
Kev noj qab haus huv ntawm daim tawv nqaij: Vitamin E paub txog nws cov tawv nqaij-nourishing zog, suav nws lub peev xwm los moisturize thiab xyuas kom cov tawv nqaij los ntawm kev puas tsuaj los ntawm tej yam ntuj tso Cheebtsam thiab UV hluav taws xob. L-glutathione ib yam nkaus txhawb kev noj qab haus huv ntawm daim tawv nqaij los ntawm kev ua kom detoxification thiab txo qis oxidative stretch, uas tuaj yeem ua rau lub ntsej muag ci dua, muaj zog dua.
Thaum noj L-glutathione thiab vitamin E ua ke, nws yog ib qho tseem ceeb uas yuav tsum tau ua raws li cov lus pom zoo noj thiab sab laj nrog tus kws kho mob yog tias koj muaj mob hauv qab no lossis noj cov tshuaj uas cuam tshuam nrog cov tshuaj no. Tsis tas li ntawd, xaiv cov khoom noj khoom haus zoo los ntawm cov npe nrov kom muaj kev nyab xeeb thiab ua tau zoo.
Understanding L-Glutathione thiab Vitamin E
Ua ntej delving rau hauv lawv compatibility, nws yog ib qho tseem ceeb kom tuav lub luag hauj lwm L-Glutathione zog thiab vitamin E ua si hauv lub cev. L-glutathione, feem ntau hu ua "tus tswv antioxidant," yog ib qho tripeptide uas muaj peb cov amino acids: cysteine, glutamate, thiab glycine. Nws ua lub luag haujlwm tseem ceeb hauv neutralizing dawb radicals, txhawb nqa cov txheej txheem detoxification, thiab txhawb kev tiv thaiv kab mob. Ntawm qhov tod tes, vitamin E encompasses ib pawg ntawm cov rog-soluble tebchaw nrog lub zog antioxidant zog, feem ntau paub txog kev tiv thaiv cell membranes los ntawm oxidative puas.
cov tseem ceeb ntawm Antioxidants hauv Health
Ob leeg L-glutathione thiab vitamin E ua haujlwm tseem ceeb ntawm lub cev tiv thaiv kab mob antioxidant. Nyob rau hauv lub ntiaj teb niaj hnub no, qhov chaw uas peb niaj hnub raug rau ib puag ncig muaj kuab paug, co toxins, thiab kev ntxhov siab, tswj kom muaj cov tshuaj antioxidant txaus yog qhov tseem ceeb rau kev noj qab haus huv thiab kev noj qab haus huv. Antioxidants ua hauj lwm los ntawm neutralizing dawb radicals, unstable molecules uas yuav ua rau cellular puas thiab pab mus rau ntau yam kab mob, xws li mob qog noj ntshav, mob plawv, thiab kev laus ntxov ntxov. Yog li ntawd, koom nrog cov khoom noj muaj txiaj ntsig antioxidant thiab cov tshuaj ntxiv rau hauv koj txoj kev noj qab haus huv tuaj yeem pab txo qis oxidative kev nyuaj siab thiab txhawb nqa lub neej ntev.
Tej zaum Synergy Ntawm L-Glutathione thiab Vitamin E
thaum L-Glutathione zog thiab vitamin E txhua yam muaj zog antioxidant zog ntawm nws tus kheej, kev tshawb fawb tawm tshiab qhia tias lawv tuaj yeem ua rau muaj kev sib koom ua ke thaum ua ke. Ib txoj kev tshawb fawb luam tawm nyob rau hauv "Journal of Nutrition" qhia tau hais tias ntxiv nrog rau L-glutathione thiab vitamin E coj mus rau kev tiv thaiv ntau dua tiv thaiv oxidative kev nyuaj siab piv rau ib leeg ntxiv. Qhov kev sib koom ua ke no tuaj yeem raug ntaus nqi rau lawv cov txheej txheem ua haujlwm ntxiv: L-glutathione ua haujlwm feem ntau hauv cellular cytosol thiab mitochondria, thaum vitamin E concentrates hauv cell membranes, muab kev tiv thaiv antioxidant.
Txhim khu kev tiv thaiv Cellular
Los ntawm kev sib xyaw L-Glutathione zog thiab vitamin E, cov tib neeg tuaj yeem txhim kho lawv cov cellular tiv thaiv kev puas tsuaj oxidative, tiv thaiv cov qauv tseem ceeb xws li DNA, proteins, thiab lipids. Oxidative stress tau cuam tshuam rau hauv cov kab mob ntawm ntau yam kab mob, nrog rau cov kab mob neurodegenerative xws li Alzheimer's thiab Parkinson's disease. Yog li ntawd, kev tiv thaiv lub cev tiv thaiv antioxidant los ntawm kev sib koom ua ke tuaj yeem tuav cov lus cog tseg hauv kev tiv thaiv lossis txo qhov kev loj hlob ntawm cov xwm txheej zoo li no. Tsis tas li ntawd, kev ua kom muaj zog antioxidant tuaj yeem txhawb nqa kev noj qab haus huv ntawm daim tawv nqaij, txhawb lub cev hluas thiab txo cov teebmeem ntawm UV hluav taws xob thiab ib puag ncig cov pa phem.
Optimal Dosage thiab Formulations
Thaum lub peev xwm sib koom ua ke ntawm L-glutathione thiab vitamin E tau cog lus, nws yog ib qho tseem ceeb uas yuav tau xav txog ntau npaum li cas thiab cov qauv tsim thaum koom nrog cov tshuaj no rau hauv koj cov kev tswj hwm. Xaiv lub npe nrov npe uas siv cov khoom xyaw zoo thiab ua raws li cov qauv tsim khoom nruj. Cov lus pom zoo noj yuav txawv nyob ntawm tus kheej yam xws li hnub nyoog, kev noj qab haus huv, thiab cov hom phiaj kev noj qab haus huv tshwj xeeb. Kev sab laj nrog tus kws kho mob tau qhia kom txiav txim siab txog qhov tsim nyog thiab cov qauv tsim kom haum rau koj cov kev xav tau tshwj xeeb.
Tej zaum sib tshuam thiab ceev faj
Txawm hais tias L-glutathione thiab vitamin E feem ntau tau txais txiaj ntsig zoo thaum noj hauv cov tshuaj pom zoo, nws tseem ceeb heev uas yuav tsum nco ntsoov txog kev sib cuam tshuam thiab kev ceev faj. Cov tib neeg noj cov tshuaj uas txo cov ntshav siab xws li warfarin yuav tsum tau ceev faj thaum sib xyaw cov tshuaj vitamin E, vim tias cov koob tshuaj ntau yuav ua rau muaj kev pheej hmoo los ntshav. Tsis tas li ntawd, cov tib neeg uas muaj qee yam kev mob nkeeg, xws li qabzib-6-phosphate dehydrogenase (G6PD) tsis txaus, yuav tsum sab laj nrog tus kws kho mob ua ntej ntxiv L-glutathione, vim nws yuav ua rau hemolysis ua rau cov neeg raug mob.
incorporating Antioxidant-nplua nuj zaub mov
Txawm hais tias kev noj tshuaj ntxiv tuaj yeem muaj txiaj ntsig zoo, nws yog qhov tseem ceeb uas yuav tsum nco ntsoov tias kev noj zaub mov kom zoo uas muaj cov khoom noj muaj antioxidant ua rau lub hauv paus ntawm kev noj qab haus huv zoo. Muab ntau yam txiv hmab txiv ntoo thiab zaub rau hauv koj cov zaub mov, vim lawv muaj ntau nyob rau hauv cov vitamins, minerals, thiab phytonutrients nrog antioxidant zog. Piv txwv li berries, nplooj ntsuab, citrus txiv hmab txiv ntoo, txiv ntseej, noob, thiab txiv roj roj. Los ntawm kev saib xyuas tag nrho cov khoom noj, koj tuaj yeem ua kom muaj zog ntxiv rau koj cov tshuaj tiv thaiv antioxidant thaum sau cov txiaj ntsig ntxiv ntawm kev noj haus fiber ntau, vitamins, thiab minerals.
xaus
Hauv kev xaus, cov lus nug ntawm seb ib tus tuaj yeem coj li cas L-Glutathione zog nrog cov vitamin E tau ntsib nrog cov lus pom zoo, txhawb nqa los ntawm cov pov thawj tshawb fawb qhia txog lawv cov peev xwm sib koom ua ke hauv kev tawm tsam oxidative kev nyuaj siab thiab txhawb kev noj qab haus huv tag nrho. Los ntawm kev nkag siab txog lub luag haujlwm ntawm cov antioxidants no, optimizing ntau npaum li cas thiab formulations, thiab nco ntsoov txog tej yam kev sib cuam tshuam thiab ceev faj, cov tib neeg tuaj yeem siv lub zog ntawm L-glutathione thiab vitamin E los txhawb lawv cov kev tiv thaiv antioxidant thiab txhawb nqa lub neej ntev. Nco ntsoov saib xyuas qhov tseem ceeb ntawm kev noj zaub mov kom muaj txiaj ntsig zoo hauv cov khoom noj muaj antioxidant thaum koom nrog cov tshuaj ntxiv rau kev noj qab haus huv. Raws li ib txwm muaj, sab laj nrog tus kws kho mob ua ntej pib cov txheej txheem ntxiv tshiab kom ntseeg tau tias muaj kev nyab xeeb thiab ua tau zoo.
References:
1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409737/
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583892/
3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897598/
Kuv puas tuaj yeem noj L-Glutathione nrog Vitamin E?
Raws li ib tus neeg paub txog kev noj qab haus huv, koj tuaj yeem pom koj tus kheej xav paub txog cov txiaj ntsig thiab kev cuam tshuam ntawm ntau yam tshuaj. Ntawm cov plethora ntawm kev xaiv muaj, L-Glutathione zog thiab vitamin E sawv tawm rau lawv cov khoom muaj npe antioxidant thiab txhawb kev noj qab haus huv. Txawm li cas los xij, ua ntej muab cov tshuaj ntxiv, nws yog ib qho tseem ceeb kom nkag siab txog lawv cov txheej txheem ntawm kev ua, kev sib cuam tshuam, thiab kev sib raug zoo tag nrho.
Yog lawm, koj tuaj yeem ua rau feem ntau noj L-glutathione nrog cov vitamin E, thiab qhov tseeb, lawv tuaj yeem txhawb nqa ib leeg los ntawm kev noj qab haus huv loj thiab tiv thaiv antioxidant. Nov yog qhov lawv tuaj yeem ua haujlwm ua ke:
Antioxidant Cooperative zog: Ob leeg L-glutathione thiab vitamin E yog cov tshuaj tiv thaiv kabmob kheesxaws uas muaj kev pabcuam kom cov hlwb los ntawm oxidative raug mob los ntawm cov dawb radicals. Dawb radicals yog cov khoom tsis ruaj khov uas tuaj yeem ua rau muaj kev puas tsuaj ntawm tes thiab ua rau muaj kev noj qab haus huv sib txawv, suav nrog kev loj hlob, ua rau hnyav dua, thiab mob tsis tu ncua. Los ntawm kev noj L-glutathione thiab vitamin E ua ke, koj tuaj yeem hloov kho koj lub cev cov tshuaj tiv thaiv antioxidant thiab rov qab rau kev noj qab haus huv.
Regeneration of Cancer Prevention agents: Ib qho ntawm cov khoom zoo ntawm L-glutathione yog nws txoj hauv kev rov qab los ntawm lwm cov tshuaj tiv thaiv kabmob kheesxaws, suav cov vitamin E. Tom qab vitamin E neutralizes dawb radical, nws tau oxidized. L-glutathione ua rau muaj qhov sib txawv rov qab oxidized vitamin E rov qab mus rau nws cov duab zoo, tso cai rau nws ua nws cov haujlwm antioxidant hauv lub cev. Qhov kev hloov pauv ntawm L-glutathione thiab vitamin E qhia txog lawv txoj kev sib koom tes hauv kev tawm tsam oxidative kev nyuaj siab.
Immune Back: Ob leeg L-glutathione thiab vitamin E ua si qhov tseem ceeb hauv kev txhawb nqa kev nyab xeeb. Los ntawm kev txo qis oxidative thawb thiab khaus khaus, lawv muab kev pabcuam kom muaj suab nrov tiv thaiv thiab tiv thaiv kab mob thiab kab mob.
Kev noj qab haus huv ntawm daim tawv nqaij: Vitamin E paub txog nws cov tawv nqaij-nourishing zog, suav nws lub peev xwm los moisturize thiab xyuas kom cov tawv nqaij los ntawm kev puas tsuaj los ntawm tej yam ntuj tso Cheebtsam thiab UV hluav taws xob. L-glutathione ib yam nkaus txhawb kev noj qab haus huv ntawm daim tawv nqaij los ntawm kev ua kom detoxification thiab txo qis oxidative stretch, uas tuaj yeem ua rau lub ntsej muag ci dua, muaj zog dua.
Thaum noj L-glutathione thiab vitamin E ua ke, nws yog ib qho tseem ceeb uas yuav tsum tau ua raws li cov lus pom zoo noj thiab sab laj nrog tus kws kho mob yog tias koj muaj mob hauv qab no lossis noj cov tshuaj uas cuam tshuam nrog cov tshuaj no. Tsis tas li ntawd, xaiv cov khoom noj khoom haus zoo los ntawm cov npe nrov kom muaj kev nyab xeeb thiab ua tau zoo.
Understanding L-Glutathione thiab Vitamin E
Ua ntej delving rau hauv lawv compatibility, nws yog ib qho tseem ceeb kom tuav lub luag hauj lwm L-Glutathione zog thiab vitamin E ua si hauv lub cev. L-glutathione, feem ntau hu ua "tus tswv antioxidant," yog ib qho tripeptide uas muaj peb cov amino acids: cysteine, glutamate, thiab glycine. Nws ua lub luag haujlwm tseem ceeb hauv neutralizing dawb radicals, txhawb nqa cov txheej txheem detoxification, thiab txhawb kev tiv thaiv kab mob. Ntawm qhov tod tes, vitamin E encompasses ib pawg ntawm cov rog-soluble tebchaw nrog lub zog antioxidant zog, feem ntau paub txog kev tiv thaiv cell membranes los ntawm oxidative puas.
cov tseem ceeb ntawm Antioxidants hauv Health
Ob leeg L-glutathione thiab vitamin E ua haujlwm tseem ceeb ntawm lub cev tiv thaiv kab mob antioxidant. Nyob rau hauv lub ntiaj teb niaj hnub no, qhov chaw uas peb niaj hnub raug rau ib puag ncig muaj kuab paug, co toxins, thiab kev ntxhov siab, tswj kom muaj cov tshuaj antioxidant txaus yog qhov tseem ceeb rau kev noj qab haus huv thiab kev noj qab haus huv. Antioxidants ua hauj lwm los ntawm neutralizing dawb radicals, unstable molecules uas yuav ua rau cellular puas thiab pab mus rau ntau yam kab mob, xws li mob qog noj ntshav, mob plawv, thiab kev laus ntxov ntxov. Yog li ntawd, koom nrog cov khoom noj muaj txiaj ntsig antioxidant thiab cov tshuaj ntxiv rau hauv koj txoj kev noj qab haus huv tuaj yeem pab txo qis oxidative kev nyuaj siab thiab txhawb nqa lub neej ntev.
Tej zaum Synergy Ntawm L-Glutathione thiab Vitamin E
thaum L-Glutathione zog thiab vitamin E txhua yam muaj zog antioxidant zog ntawm nws tus kheej, kev tshawb fawb tawm tshiab qhia tias lawv tuaj yeem ua rau muaj kev sib koom ua ke thaum ua ke. Ib txoj kev tshawb fawb luam tawm nyob rau hauv "Journal of Nutrition" qhia tau hais tias ntxiv nrog rau L-glutathione thiab vitamin E coj mus rau kev tiv thaiv ntau dua tiv thaiv oxidative kev nyuaj siab piv rau ib leeg ntxiv. Qhov kev sib koom ua ke no tuaj yeem raug ntaus nqi rau lawv cov txheej txheem ua haujlwm ntxiv: L-glutathione ua haujlwm feem ntau hauv cellular cytosol thiab mitochondria, thaum vitamin E concentrates hauv cell membranes, muab kev tiv thaiv antioxidant.
Txhim khu kev tiv thaiv Cellular
Los ntawm kev sib xyaw L-Glutathione zog thiab vitamin E, cov tib neeg tuaj yeem txhim kho lawv cov cellular tiv thaiv kev puas tsuaj oxidative, tiv thaiv cov qauv tseem ceeb xws li DNA, proteins, thiab lipids. Oxidative stress tau cuam tshuam rau hauv cov kab mob ntawm ntau yam kab mob, nrog rau cov kab mob neurodegenerative xws li Alzheimer's thiab Parkinson's disease. Yog li ntawd, kev tiv thaiv lub cev tiv thaiv antioxidant los ntawm kev sib koom ua ke tuaj yeem tuav cov lus cog tseg hauv kev tiv thaiv lossis txo qhov kev loj hlob ntawm cov xwm txheej zoo li no. Tsis tas li ntawd, kev ua kom muaj zog antioxidant tuaj yeem txhawb nqa kev noj qab haus huv ntawm daim tawv nqaij, txhawb lub cev hluas thiab txo cov teebmeem ntawm UV hluav taws xob thiab ib puag ncig cov pa phem.
Optimal Dosage thiab Formulations
Thaum lub peev xwm sib koom ua ke ntawm L-glutathione thiab vitamin E tau cog lus, nws yog ib qho tseem ceeb uas yuav tau xav txog ntau npaum li cas thiab cov qauv tsim thaum koom nrog cov tshuaj no rau hauv koj cov kev tswj hwm. Xaiv lub npe nrov npe uas siv cov khoom xyaw zoo thiab ua raws li cov qauv tsim khoom nruj. Cov lus pom zoo noj yuav txawv nyob ntawm tus kheej yam xws li hnub nyoog, kev noj qab haus huv, thiab cov hom phiaj kev noj qab haus huv tshwj xeeb. Kev sab laj nrog tus kws kho mob tau qhia kom txiav txim siab txog qhov tsim nyog thiab cov qauv tsim kom haum rau koj cov kev xav tau tshwj xeeb.
Tej zaum sib tshuam thiab ceev faj
Txawm hais tias L-glutathione thiab vitamin E feem ntau tau txais txiaj ntsig zoo thaum noj hauv cov tshuaj pom zoo, nws tseem ceeb heev uas yuav tsum nco ntsoov txog kev sib cuam tshuam thiab kev ceev faj. Cov tib neeg noj cov tshuaj uas txo cov ntshav siab xws li warfarin yuav tsum tau ceev faj thaum sib xyaw cov tshuaj vitamin E, vim tias cov koob tshuaj ntau yuav ua rau muaj kev pheej hmoo los ntshav. Tsis tas li ntawd, cov tib neeg uas muaj qee yam kev mob nkeeg, xws li qabzib-6-phosphate dehydrogenase (G6PD) tsis txaus, yuav tsum sab laj nrog tus kws kho mob ua ntej ntxiv L-glutathione, vim nws yuav ua rau hemolysis ua rau cov neeg raug mob.
incorporating Antioxidant-nplua nuj zaub mov
Txawm hais tias kev noj tshuaj ntxiv tuaj yeem muaj txiaj ntsig zoo, nws yog qhov tseem ceeb uas yuav tsum nco ntsoov tias kev noj zaub mov kom zoo uas muaj cov khoom noj muaj antioxidant ua rau lub hauv paus ntawm kev noj qab haus huv zoo. Muab ntau yam txiv hmab txiv ntoo thiab zaub rau hauv koj cov zaub mov, vim lawv muaj ntau nyob rau hauv cov vitamins, minerals, thiab phytonutrients nrog antioxidant zog. Piv txwv li berries, nplooj ntsuab, citrus txiv hmab txiv ntoo, txiv ntseej, noob, thiab txiv roj roj. Los ntawm kev saib xyuas tag nrho cov khoom noj, koj tuaj yeem ua kom muaj zog ntxiv rau koj cov tshuaj tiv thaiv antioxidant thaum sau cov txiaj ntsig ntxiv ntawm kev noj haus fiber ntau, vitamins, thiab minerals.
xaus
Hauv kev xaus, cov lus nug ntawm seb ib tus tuaj yeem coj li cas L-Glutathione zog nrog cov vitamin E tau ntsib nrog cov lus pom zoo, txhawb nqa los ntawm cov pov thawj tshawb fawb qhia txog lawv cov peev xwm sib koom ua ke hauv kev tawm tsam oxidative kev nyuaj siab thiab txhawb kev noj qab haus huv tag nrho. Los ntawm kev nkag siab txog lub luag haujlwm ntawm cov antioxidants no, optimizing ntau npaum li cas thiab formulations, thiab nco ntsoov txog tej yam kev sib cuam tshuam thiab ceev faj, cov tib neeg tuaj yeem siv lub zog ntawm L-glutathione thiab vitamin E los txhawb lawv cov kev tiv thaiv antioxidant thiab txhawb nqa lub neej ntev. Nco ntsoov saib xyuas qhov tseem ceeb ntawm kev noj zaub mov kom muaj txiaj ntsig zoo hauv cov khoom noj muaj antioxidant thaum koom nrog cov tshuaj ntxiv rau kev noj qab haus huv. Raws li ib txwm muaj, sab laj nrog tus kws kho mob ua ntej pib cov txheej txheem ntxiv tshiab kom ntseeg tau tias muaj kev nyab xeeb thiab ua tau zoo.
References:
1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409737/
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583892/
3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897598/
